[1]柳静,黄燕,王立波,等.小儿止咳糖浆治疗小儿急性支气管炎的临床研究[J].中医儿科杂志,2017,(04):33-37.[doi:10.16840/j.issn1673-4297.2017.04.11]
 LIU Jing,HUANG Yan,WANG Libo,et al.Clinical trial on the effect of Xiao’er Zhike Syrup in treating infantile acute bronchitis[J].Journal of Pediatrics of Traditional Chinese Medicine,2017,(04):33-37.[doi:10.16840/j.issn1673-4297.2017.04.11]
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小儿止咳糖浆治疗小儿急性支气管炎的临床研究
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《中医儿科杂志》[ISSN:/CN:62-1176/R]

卷:
期数:
2017年04期
页码:
33-37
栏目:
临床研究与报道
出版日期:
2017-07-25

文章信息/Info

Title:
Clinical trial on the effect of Xiao’er Zhike Syrup in treating infantile acute bronchitis
作者:
柳静1 黄燕2 王立波3 马红玲4 尚云晓5 周小勤6 万莉雅7 尹永日8 胡思源9 闫慧敏1
1. 首都医科大学附属北京儿童医院中医科, 北京 100045;
2. 大连市儿童医院呼吸科, 辽宁 大连 116012;
3. 复旦大学附属儿科医院呼吸科, 上海 200032;
4. 深圳市儿童医院呼吸科, 广东 深圳 518026
Author(s):
LIU Jing1 HUANG Yan2 WANG Libo3 MA Hongling4 SHANG Yunxiao5 ZHOU Xiaoqin6 WAN Liya7 YIN Yongri8 HU Siyuan9 YAN Huimin1
1. TCM Department of Beijing Children’s Hospital Affiliated to Capital Medical University, Beijing, 100045, China;
2. Respiratory Department, Children’s Hospital of Dalian, Dalian, Liaoning, 116012, China;
3. Respiratory Department, Children’s Hospital of Fudan University, Shanghai, 200032, China;
4. Respiratory Department, Children’s Hospital of Shenzhen, Shenzhen, Guangdong, 518026, China
关键词:
小儿急性支气管炎咳嗽小儿止咳糖浆临床研究
Keywords:
infantile acute bronchitiscoughXiao’er Zhike Syrupclinical trial
分类号:
R256.11
DOI:
10.16840/j.issn1673-4297.2017.04.11
摘要:
目的 评价小儿止咳糖浆治疗小儿急性支气管炎咳嗽、咳痰症状的临床有效性和安全性。方法 采用盲法、分层区组随机、多中心、双阳性对照临床研究的方法,8家参研单位实际纳入患儿360例,随机分为治疗组、对照组1和对照组2,每组120例,治疗组给予小儿止咳糖浆口服,对照组1给予盐酸氨溴索口服溶液口服,对照组2给予小儿化痰止咳颗粒开水冲服,3组均治疗5 d后统计疗效。结果 3组咳嗽(日咳+夜咳)评分与治疗时间曲线下面积(AUC)比较,差异有统计学意义(P<0.01);两两比较,治疗组优于对照组1,差异有统计学意义(P<0.01)。咳痰难易度评分与治疗时间AUC比较,3组间比较差异均无统计学意义(P>0.05)。治疗后3组愈显率比较,差异有统计学意义(P<0.05),治疗组与对照组1比较有统计学意义(P<0.01)。治疗后3组在日咳、夜咳、咳痰难易度、痰量、痰的性状方面比较,差异均有统计学意义(P<0.05)。3组不良反应比较,差异均无统计学意义(P>0.05)。结论 小儿止咳糖浆在治疗小儿急性支气管炎咳嗽、咳痰症状方面疗效显著、安全性好、依从性高。
Abstract:
Objective To evaluate the clinical effectiveness and safety of Xiao’er Zhike Syrup in treating cough and phlegm symptom of infantile acute bronchitis.Methods Applied blinding,stratified blocked randomization,multi-center and double positive control method, 360 cases from 8 hospitals were divided into therapy group, control group 1 and control group 2 with 120 cases in each.The therapy group was given Xiao’er Zhike Syrup,while the control group 1 was treated with Ambroxol Hydrochloride Oral Solution, the control group 2 with Xiao’er Zhike granules.The clinical effects of three were observed after 5 days.Results There were significant differences in the cough (day cough and night cough) score and the area under the curve (AUC) among three groups (P<0.01);these were better in therapy group than in the control group1 with significant differences (P<0.01).Comparing phlegm score with treatment time ACU,there were no significant differences among three groups (P>0.05).There were significant differences in cure-remarkable-effectiveness rate among three groups after treatment (P<0.05),the statistical difference of clinical effect between the therapy group and control group 1 was significant (P<0.01). After treatment,there were significant differences in day cough and night cough,phlegm,quality and the quantity of phlegm among three groups(P<0.05).Untoward effects in three groups had no significant differences (P>0.05).Conclusion Xiao’er Zhike Syrup has a reliable efficacy,high safety and good compliance on treating cough and phlegm symptom of infantile acute bronchitis.

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备注/Memo

备注/Memo:
收稿日期:2016-08-11。
作者简介:柳静(1963-),女,主任医师,医学学士,主要从事中西医结合儿科临床工作。
通信作者:闫慧敏(1954-),女,主任医师,教授,博士生导师,医学硕士。研究方向:小儿呼吸、消化系统疾病的研究。E-mail:huiminyan@sina.com
更新日期/Last Update: 1900-01-01