[1]孙凤平,葛国岚,韩雪,等.补中助长颗粒治疗学龄前特发性身材矮小20例临床观察[J].中医儿科杂志,2017,(04):57-60.[doi:10.16840/j.issn1673-4297.2017.04.18]
 Sun Fengping,Ge Guolan,Han Xue,et al.Clinical observation on 20 cases of idiopathic short stature in preschool children treated with Buzhong Zhuzhang Granules[J].Journal of Pediatrics of Traditional Chinese Medicine,2017,(04):57-60.[doi:10.16840/j.issn1673-4297.2017.04.18]
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补中助长颗粒治疗学龄前特发性身材矮小20例临床观察
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《中医儿科杂志》[ISSN:/CN:62-1176/R]

卷:
期数:
2017年04期
页码:
57-60
栏目:
临床研究与报道
出版日期:
2017-07-25

文章信息/Info

Title:
Clinical observation on 20 cases of idiopathic short stature in preschool children treated with Buzhong Zhuzhang Granules
作者:
孙凤平1 葛国岚1 韩雪1 崔伟锋2
1. 郑州市儿童医院中医科, 河南 郑州 450053;
2. 河南省中医药研究院科研科, 河南 郑州 450000
Author(s):
Sun Fengping1 Ge Guolan1 Han Xue1 Cui Weifeng2
1. Department of Chinese Medicine, the Children’s Hospital of Zhengzhou, Zhengzhou, Henan, 450053, China;
2. Department of Scientific Research, Henan Chinese Medicine Institute, Zhengzhou, Henan, 450000, China
关键词:
特发性身材矮小学龄前补中助长颗粒临床观察
Keywords:
idiopathic short staturepreschoolBuzhong Zhuzhang Granulesclinical observation
分类号:
R272.6
DOI:
10.16840/j.issn1673-4297.2017.04.18
摘要:
目的 观察补中助长颗粒治疗学龄前特发性身材矮小(ISS)的临床疗效。方法 将40例学龄前ISS患儿随机分为对照组和治疗组,对照组给予生活方式干预,治疗组在对照组治疗方法的基础上口服补中助长颗粒,2次/d,4个疗程后比较2组患儿身高(H)、身高增长速度(GV)、身高标准差计数(HtSDS)、体质量指数(BMI)、年龄/骨龄(CA/BA)、预测成人身高(PAH)的差异以及血清胰岛素样生长因子1(IGF-1)、生长激素激发试验所得生长激素峰值(GHP)的变化。结果 治疗后2组BMI,CA/BA比较,差异均无统计学意义(P>0.05),治疗组GV、PAH、血清IGF-1、GHP、HtSDS高于对照组,差异均有统计学意义(P<0.05或P<0.01)。结论 补中助长颗粒能够促进ISS患儿生长,刺激ISS患儿血清IGF-1和生长激素(GH)的表达可能是其作用机制之一。
Abstract:
Objective To observe the clinical effect of idiopathic short stature(ISS) in preschool children treated with Buzhong Zhuzhang Granules.Methods 40 cases of preschool children with ISS were randomly divided into control group and therapy group.The control group was given lifestyle intervention,while the therapy group was given Buzhong Zhuzhang Granule twice a day based on the therapy of control group.After 4 courses of treatment,data of children’s H,GV,HtSDS,BMI,CA/BA,PAH and changes of IGF-1,GHP were observed and compared.Results After treatment, there were no statistical significant differences in comparison of BMI,CA/B of two groups (P>0.05).The degree of GV,PAH,IGF-1,GHP,HtSDS in the therapy group were higher than that of control group,differences had statistical significance (P<0.05 or P<0.01).Conclusion Buzhong Zhuzhang Granules can improve ISS,stimulate IGF-1 and GH.

参考文献/References:

[1] Bright G M,Rogol A D,Johan,et al. Short stature associated with normal growth hormone and decreased somatomedin-C concentration:response to exogenous growth hormone[J]. Pediatrics,1983,71(4):576-580.
[2] Cohen P,Rogol A D,Deal C L,et al.Consensus statement on the diagnosis and treatment of children with idiopathic short stature:a summary of the Growth Hormone Research Society,the Lawson Wilkins Pediatric Endocrine Society,and the European Society for Paediatric Endocrinology Workshop[J].J Clin Endocrinol Metab,2008,93(11):4210-4217.
[3] 国家中医药管理局.中医病证诊断疗效标准[S].南京:南京大学出版社,1994:290.
[4] 中华人民共和国卫生部.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:67.
[5] 李辉,季成叶,宗心南,等.中国0~18岁儿童、青少年身高、体重的标准化生长曲线[J].中华儿科杂志,2009,47(7):487-492.
[6] Lindsay R,Feldkamp M,Harris D,et al.Utah Growth Study:growth standards and the prevalence of growth hormone deficiency[J].J Pediatr,1994,125(1):29-35.
[7] 倪佳,辛颖.儿童特发性矮小的诊治进展[J].中国中西医结合儿科学,2015,7(3):199-202.
[8] 董治亚,王伟,杜晓飞,等.人生长激素同型异构体比例变化与特发性矮小症的相关性[J].临床儿科杂志,2006,24(12):974-976.
[9] De Bellis A,Colao A,Tirelli G,et al.Autoimmunity as a possible cause of growth hormone deficiency[J].J Endocrinol Invest,2008,31(12):1132-1134.
[10] Aalbers A M,Chin D,Pratt K L,et al.Extreme elevation of serum growth hormone-binding protein concentrations resulting from a novel heterozygous splice site mutation of the growth hormone receptor gene[J].Horm Res,2009,71(5):276-284.
[11] Pongcharoen T,Digirolamo A M,Ramakrishnan U,et al.Long-term effects of iron and zinc supplementation during infancy on cognitive function at 9 y of age in northeast Thai children:a follow-up study[J].Am J Clin Nutr,2011,93(3):636-643.
[12] Noda M,Sato N,Tanaka T.Growth failure starts from early infancy in children with short stature at age 6[J].Clin Pediatr Endocrinol,2015,24(1):1-10.
[13] Salerno M,Balestrieri E,Matrecano,et al.Abnormal GH receptor signaling in children with idopathic short stature[J].J Clin Endocrinol Metab,2001,86(8):3882-3888.
[14] Lysette Iglesias,James K.Yeh,Mariano Castro-Magana,et al.Effects of growth hormone on bone modeling and remo- deling in hypophysectomized young female rats:a bone histomorphometric study[J].Journal of Bone and Mineral Metabolism,2011,29(2):159-167.
[15] Haghshenas Z,Sotoudeh K,Karamifar H,et al.The role of insulin like growth factor (IGF)-1 and IGF-binding protein-3 in diagnosis of Growth Hormone Deficiency in short stature children[J].Indian J Pediatr,2009,76(7):699-703.
[16] Sklar Z,Kocaay P,amtosun E,et al. The effect of recombinant growth hormone treatment in children with idiopathic short stature and low insulin-like growth factor-1 levels[J].J Clin Res Pediatr Endocrinol,2015,7(4):301-306.
[17] Jeong H R,Shim Y S,Lee H S,et al.The effect of growth hormone treatment on height in children with idiopathic short stature[J].J Pediatr Endocrinol Metab,2014,27(7-8):629-633.
[18] 舒畅,潘慧.重组人生长激素治疗儿童生长激素缺乏症和特发性矮小症的安全性问题[J].中国医学科学院学报,2012,33(2):123-126.
[19] 李桂梅.实用儿科内分泌与遗传代谢病[M].济南:山东科学技术出版社,2015:190.

备注/Memo

备注/Memo:
收稿日期:2016-10-10。
基金项目:河南省中医药科学研究专项课题(2015ZY02115);河南省中医药研究专项课题(2015ZY02073);河南省科技攻关项目(162102310063)。
作者简介:孙凤平(1981-),男,主治医师,医学博士。研究方向:中医药防治小儿生长发育异常的临床和实验研究。
通信作者:崔伟锋(1980-),男,副主任医师,医学硕士。研究方向:临床疗效评价。Tel:13598406417。
更新日期/Last Update: 1900-01-01