[1]安黎,戴启刚,张雅婷,等.槐杞黄颗粒联合常规对症治疗儿童反复呼吸道感染的Meta分析研究[J].中医儿科杂志,2018,14(05):1-6.[doi:10.16840/j.issn1673-4297.2018.05.01]
 AN Li,DAI Qigang,ZHANG Yating,et al.Meta-analysis of Huaiqihuang Granules(槐芪黄颗粒) combined with conventional symptomatic treatment on recurrent respiratory tract infection in children[J].Journal of Pediatrics of Traditional Chinese Medicine,2018,14(05):1-6.[doi:10.16840/j.issn1673-4297.2018.05.01]
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槐杞黄颗粒联合常规对症治疗儿童反复呼吸道感染的Meta分析研究()
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《中医儿科杂志》[ISSN:/CN:62-1176/R]

卷:
14
期数:
2018年05期
页码:
1-6
栏目:
论著
出版日期:
2018-09-25

文章信息/Info

Title:
Meta-analysis of Huaiqihuang Granules(槐芪黄颗粒) combined with conventional symptomatic treatment on recurrent respiratory tract infection in children
作者:
安黎1 戴启刚1 张雅婷2 汪受传1
1. 南京中医药大学附属医院儿科, 江苏 南京 210029;
2. 淮安市洪泽区中医院科教科, 江苏 淮安 210031
Author(s):
AN Li1 DAI Qigang1 ZHANG Yating2 WANG Shouchuan1
1. Department of Pediatrics, Hospital Affiliated to Nanjing University of TCM, Nanjing, Jiangsu, 210029, China;
2. Research and Education Section, Hongze Hospital of TCM, Huai’an, Jiangsu, 223100, China
关键词:
儿童反复呼吸道感染槐杞黄颗粒Meta分析
Keywords:
childrenrecurrent respiratory tract infectionHuaiqihuang GranulesMeta-analysis
分类号:
R256.1
DOI:
10.16840/j.issn1673-4297.2018.05.01
摘要:
目的 通过Meta分析,研究槐杞黄颗粒联合常规对症治疗儿童反复呼吸道感染的有效性。方法 计算机检索中国期刊全文数据库(CNKI)、万方数据知识服务平台、中文科技期刊数据库(维普)、中国生物医学文献服务系统(SinoMed)以及PubMed、EMBASE、the Cochrane Library等,收集槐杞黄颗粒对儿童反复呼吸道感染的疗效和免疫功能影响的随机对照试验研究,检索时限从建库至2018年5月。由2位研究者按照纳入与排除标准筛选文献,提取数据并参考改良Jadad量表评定文献质量后,采用Rev Man5.3软件进行Meta分析。结果 13篇采用随机对照试验研究文献中,仅有1篇文献描述了采用随机数字表法进行分组;5篇文献统计了平均病程,9篇文献记载了不良事件;11篇文献报道了总有效率,治疗组和对照组的总有效率比较,差异有统计学意义(P<0.001);9篇文献比较了治疗组和对照组的免疫球蛋白(Ig)A、IgG和IgM抗体水平,IgA、IgG抗体水平方面,治疗组均优于对照组(P<0.001),IgM抗体水平比较,差异无统计学意义(P>0.05);3篇文献比较了治疗组和对照组的CD3+、CD4+、CD8+和CD4+/CD8+水平差异,结果表明治疗组在提高患儿CD3+、CD4+ T细胞方面优于对照组(P<0.01)。Meta分析通过逐一剔除文献方法进行敏感性分析,没有找到影响总体异质性的某些文献。结论 槐杞黄颗粒联合常规对症治疗儿童反复呼吸道感染的总体疗效优于单纯常规对症治疗,且在改善临床症状、提高易感儿抗体水平和CD3+、CD4+ T细胞水平方面更具优势,临床安全性较高。
Abstract:
Objective To evaluate the clinical efficacy of Huaiqihuang Granules combined with conventional symptomatic treatment for recurrent respiratory tract infection (RRTI) in children by Meta-analysis.Methods To search the related literatures from the databases by computer from China Academic Journal Network Publishing Database,Wanfang Data Knowledge Service Platform,VIP Database for Chinese Technical Periodicals,SinoMed,PubMed,EMBASE and the Cochrane Library to investigate the clinical and immune effect of Huaiqihuang Granules on RRTI in children dated from inception to May,2018.The literature was screened according to the inclusion and exclusion criteria by 2 researchers.After the data were extracted and the methodological quality of studies were evaluated with reference to modified Jadad scale,the Meta-analysis was performed by the software Rev Man 5.3.Results Among 13 articles conducting randomized controlled trial,only 1 of them describing that random number table method was used for grouping;5 of them counting the mean duration of disease,9 of them recording adverse events;11 of them reported total effective rates,making comparison of total effective rates between treatment group and control group,there was statistic difference between them(P<0.001).9 of them compared the antibody levels of IgA,IgG and IgM in treatment group and control group,the antibody levels of IgA,IgG in treatment group were superior to those in control group(P<0.001),while comparing the antibody level of IgM,there was no statistic difference (P>0.05).3 of them compared the level differences of CD3+,CD4+,CD8+ and CD4+/CD8+ in treatment group and control group,the former was superior to the latter in increasing CD3+,CD4+ of the children (P<0.001).Meta-analysis performed sensitivity analyses by culling method,no article was found on affecting overall heterogeneity.Conclusion The overall efficacy of Huaiqihuang Granules combined with conventional symptomatic treatment on treating RRTI in children was superior to that of the conventional symptomatic treatment.It has more advantages in improving clinical symptoms,increasing the antibody levels,CD3+,CD4+ T cell levels,and it has high security for clinical use.

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备注/Memo

备注/Memo:
收稿日期:2018-07-08。
基金项目:全国名中医工作室建设项目(国中医药人教函[2018]119号)。
作者简介:安黎(1993-),女,在读硕士研究生。研究方向:小儿肺系疾病。
通信作者:汪受传(1946-),男,教授,主任医师,博士生导师,医学硕士,主要从事小儿肺系疾病及中医标准化研究。E-mail:wscnj@126.com
更新日期/Last Update: 1900-01-01