[1]伊燕军,王真,徐旭.清胃散加味辅助治疗小儿复发性口腔溃疡脾胃伏火型42例临床观察[J].中医儿科杂志,2019,15(01):45-48.[doi:10.16840/j.issn1673-4297.2019.01.16]
 YI Yanjun,WANG Zhen,XU Xu.Clinical observation on modified Qingwei San (清胃散) in adjuvant treatment for 42 cases of recurrent oral ulcer in children with latent fire in spleen and stomach type[J].Journal of Pediatrics of Traditional Chinese Medicine,2019,15(01):45-48.[doi:10.16840/j.issn1673-4297.2019.01.16]
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清胃散加味辅助治疗小儿复发性口腔溃疡脾胃伏火型42例临床观察
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《中医儿科杂志》[ISSN:/CN:62-1176/R]

卷:
15
期数:
2019年01期
页码:
45-48
栏目:
临床研究与报道
出版日期:
2019-01-25

文章信息/Info

Title:
Clinical observation on modified Qingwei San (清胃散) in adjuvant treatment for 42 cases of recurrent oral ulcer in children with latent fire in spleen and stomach type
作者:
伊燕军 王真 徐旭
衢州市人民医院口腔科, 浙江 衢州 324000
Author(s):
YI Yanjun WANG Zhen XU Xu
Department of Stomatology, the People's Hospital of Quzhou, Quzhou, Zhejiang, 324000, China
关键词:
复发性口腔溃疡小儿脾胃伏火型清胃散临床观察
Keywords:
recurrent oral ulcer (ROU)childrenlatent fire in spleen and stomach typeQingwei San (清胃散)clinical observation
分类号:
R781.5
DOI:
10.16840/j.issn1673-4297.2019.01.16
摘要:
目的 观察清胃散加味辅助治疗小儿复发性口腔溃疡脾胃伏火型的临床疗效。方法 将84例复发性口腔溃疡脾胃伏火型患儿随机分为对照组和治疗组,各42例。对照组予以常规西药治疗,治疗组在对照组治疗方法的基础上联合清胃散加味治疗,2组均治疗2周后比较临床疗效、溃疡愈合时间、疼痛视觉模拟量表(VAS)评分以及外周血T淋巴细胞亚群水平变化情况。结果 对照组总有效率为78.57%,治疗组为95.24%,2组比较,差异有统计学意义(P<0.05)。对照组溃疡愈合时间为(5.68±1.02)d,治疗组为(3.78±1.02)d,2组比较,差异有统计学意义(P<0.05)。2组治疗前疼痛VAS评分比较,差异无统计学意义(P>0.05),具有可比性。治疗后2组疼痛VAS评分均显著下降,与同组治疗前比较,差异有统计学意义(P<0.05),且治疗组下降更明显(P<0.05)。2组治疗前CD4+、CD8+、CD4+/CD8+水平比较,差异均无统计学意义(P>0.05),具有可比性。治疗后2组CD4+、CD4+/CD8+明显升高,CD8+明显降低,与同组治疗前比较,差异均有统计学意义(P<0.05或P<0.01),且治疗组升高或降低更显著(P<0.05)。结论 清胃散加味辅助治疗小儿复发性口腔溃疡脾胃伏火型临床疗效显著,可明显缩短口腔溃疡愈合时间,减轻疼痛程度,提高免疫功能。
Abstract:
Objective To observe the clinical efficacy of modified Qingwei San (清胃散) in adjuvant treatment of recurrent oral ulcer (ROU) in children with latent fire in spleen and stomach type.Methods Eighty-four children patients of ROU with latent fire in spleen and stomach type were randomly divided into control group and treatment group,with 42 cases in each.The control group was given the routine Western medicine, while the treatment group was given combined modified Qingwei San on the basis of the control group.After the 2 groups were both treated for 2 weeks,the clinical efficacy,the ulcer healing time,visual analogue scale (VAS) scores,and changes in peripheral blood T lymphocytes subsets were compared.Results The total effective rate of the control group was 78.57%,that of the treatment group was 95.24%,there was statistically significant difference between the two group (P<0.05).The ulcer healing time of the control group was (5.68±1.02) days,that of the treatment group was (3.78±1.02) days,there was statistically significant difference between the two groups (P<0.05).Before treatment,there was no statistically significant difference in VAS scores between the two groups (P>0.05),and they were comparable;after treatment,the VAS scores of the two groups both significantly decreased,there was statistically significant difference compared with the same group before treatment (P<0.05),moreover, the decrease was more significant in the treatment group (P<0.05). Before treatment,there was no statistically significant difference in the CD4+, CD8+,CD4+/CD8+ levels between the two groups (P>0.05),and they were comparable. After treatment,the CD4+,CD4+/CD8+ levels were significantly increased, while CD8+ levels significantly decreased in the two groups,and there was statistically significant difference compared with the same group before treatment (P<0.05 or P<0.01),moreover,the increase or decrease in the treatment group was more significant (P<0.05).Conclusion Modified Qingwei San in adjuvant treatment of ROU in children with latent fire in spleen and stomach type has significant clinical efficacy,which can markedly shorten the ulcer healing time,alleviate the pain degree,and improve the immunologic function.

参考文献/References:

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备注/Memo

备注/Memo:
基金项目:衢州市科技局项目(20172030)。
作者简介:伊燕军(1978-),男,副主任医师,医学学士,主要从事口腔科临床诊疗工作。
更新日期/Last Update: 1900-01-01