[1]马晓慧,罗晓明,陈小红.玉屏风散对过敏性紫癜患儿激素应用时间及免疫功能调节的影响[J].中医儿科杂志,2019,15(01):59-62.[doi:10.16840/j.issn1673-4297.2019.01.20]
 MA Xiaohui,LUO Xiaoming,CHEN Xiaohong.Effects of Yupingfeng San (玉屏风散) in hormone application time and immune regulation in children with Henoch-Schonlein purpura[J].Journal of Pediatrics of Traditional Chinese Medicine,2019,15(01):59-62.[doi:10.16840/j.issn1673-4297.2019.01.20]
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玉屏风散对过敏性紫癜患儿激素应用时间及免疫功能调节的影响
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《中医儿科杂志》[ISSN:/CN:62-1176/R]

卷:
15
期数:
2019年01期
页码:
59-62
栏目:
临床研究与报道
出版日期:
2019-01-25

文章信息/Info

Title:
Effects of Yupingfeng San (玉屏风散) in hormone application time and immune regulation in children with Henoch-Schonlein purpura
作者:
马晓慧1 罗晓明2 陈小红1
1. 海宁市中心医院儿科, 浙江 海宁 314408;
2. 浙江省人民医院儿科, 浙江 杭州 310014
Author(s):
MA Xiaohui1 LUO Xiaoming2 CHEN Xiaohong1
1. Department of Pediatrics, Haining Central Hospital, Haining, Zhejiang, 314408, China;
2. Department of Pediatrics, Zhejiang the People's Hospital, Hangzhou, Zhejiang, 310014, China
关键词:
过敏性紫癜儿童玉屏风散激素免疫调节临床研究
Keywords:
Henoch-Schonlein purpurachildrenYupingfeng San (玉屏风散)hormoneimmunity regulationclinical research
分类号:
R593.1
DOI:
10.16840/j.issn1673-4297.2019.01.20
摘要:
目的 探讨玉屏风散对过敏性紫癜(HSP)患儿激素应用时间及免疫功能调节的影响。方法 选取2012年12月至2017年12月在海宁市中心医院治疗的HSP患儿60例,采用随机数字表法分为治疗组和对照组,各30例。对照组给予常规对症治疗,治疗组在对照组治疗方法的基础上给予玉屏风散治疗。2组均治疗4周后,观察和记录临床疗效、临床症状缓解时间、免疫功能、激素应用减少时间、不良反应发生情况。结果 治疗组总有效率为93.33%,明显高于对照组的73.33%,2组比较,差异有统计学意义(P<0.05)。治疗组在紫癜、胃肠道症状、关节肿痛、皮疹缓解时间及激素应用减少时间方面均显著短于对照组,差异有统计学意义(P<0.05)。治疗前,2组IgA、IgE、IgG水平比较,差异均无统计学意义(P>0.05),具有可比性;与同组治疗前比较,治疗后2组IgA、IgE水平均明显降低(P<0.05),且治疗组降幅显著优于对照组(P<0.05);2组治疗前后IgG水平比较,差异无统计学意义(P>0.05)。治疗组和对照组的不良反应总发生率分别为13.33%,9.99%,2组比较,差异无统计学意义(P>0.05)。结论 玉屏风散辅助治疗HSP患儿,不仅可有效改善临床症状、免疫功能,而且还可减少激素应用时间和提高疗效,安全性良好,值得临床推广应用。
Abstract:
Objective To explore the effects of Yupingfeng San (玉屏风散) in hormone application time and immune regulation in children with Henoch-Schonlein purpura (HSP).Methods Sixty children with HSP were chosen from December 2012 to December 2017 in Haining Central hospital,and they were divided into treatment group and control group according to the random number table method,30 cases in each one.The control group was given routine symptomatic treatment,while the treatment group was given Yupingfeng San therapy on the basis of the control group.After both groups were treated for 4 weeks,the clinical efficacy,remission time of clinical symptoms, immune function,hormone reduction time,the incidence of adverse reactions in the 2 groups were observed and recorded.Results The total effective rate of the treatment group was 93.33%,which was significantly higher than 73.33% of the control group,the difference was statistically significant between the two groups (P<0.05).The time of purpura,gastrointestinal tract symptoms,joint swelling and pain,rash,hormone application reduction time in the treatment group were significantly shorter than those in the control group,the differences were statistically significant (P<0.05).Before treatment,there was no significant difference in the levels of IgA,IgE and IgG between the 2 groups (P>0.05),they were comparable. Compared with the same group before treatment,the levels of IgA and IgE in the 2 groups after treatment were significantly decreased (P<0.05),moreover,the decrease extent was more significant in the treatment group (P<0.05).There was no significant difference in the level of IgG between the 2 groups before and after treatment (P>0.05).The adverse reactions rates in the treatment group and the control group were 13.33% and 9.99% respectively,and the difference was not statistically significant between the two groups (P>0.05).Conclusion Yupingfeng San in adjuvant treatment of children with HSP can effectively improve the clinical symptoms and immune function,and it is beneficial to reduce the hormone application time and improve the therapeutic effect.With good security,it deserves clinical promotion and application.

参考文献/References:

[1] 高旅,张焱,袁叶,等.贾六金主任医师从"湿"论治小儿过敏性紫癜的经验[J].中医儿科杂志,2015,11(6):11-12.
[2] 王莉.玉屏风散颗粒治疗儿童反复呼吸道感染的疗效观察[J].实用心脑肺血管病杂志,2014,22(9):98.
[3] 中华医学会儿科学分会免疫学组,《中华儿科杂志》编辑委员会.儿童过敏性紫癜循证诊疗建议[J].中华儿科杂志,2013,51(5):502-507.
[4] 丁樱,孙晓旭,毕玲莉,等.过敏性紫癜中医诊疗指南[J].中医儿科杂志,2011,7(6):1-4.
[5] 李晓玲,王芳,吕燕.小儿过敏性紫癜的护理体会[J].健康研究,2017,37(1):105-106.
[6] 许毅,龙思敏,李艳,等.芪卿消癜汤对过敏性紫癜患者免疫球蛋白和补体水平影响的临床研究[J].上海中医药杂志,2016,50(7):56-58.
[7] 崔二旗,马苗林,冯斌.玉屏风散合金水六君煎加减治疗小儿反复呼吸道感染脾肾两虚证临床研究[J].河南中医,2016,36(8):1410-1412.
[8] 卫娜,王晓晓,王映棋,等.玉屏风散加味方对慢性阻塞性肺疾病大鼠气道炎症微环境的影响[J].现代中西医结合杂志,2018,27(5):457-461.

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备注/Memo

备注/Memo:
作者简介:马晓慧(1983-),女,主治中医师,医学学士,主要从事儿科临床诊疗工作。
通信作者:陈小红(1948-),女,副主任医师,医学硕士,主要从事儿科临床诊疗工作。E-mail:1945670495@qq.com
更新日期/Last Update: 1900-01-01