[1]陈红梅,林洁琪,陈燊.中西医结合治疗小儿幽门螺杆菌相关性十二指肠球部溃疡55例临床观察[J].中医儿科杂志,2019,15(01):66-70.[doi:10.16840/j.issn1673-4297.2019.01.22]
 CHEN Hongmei,LIN Jieqi,CHEN Shen.Clinical observation on combination of traditional Chinese and Western medicine in the treatment of Helicobacter Pylori-related duodenal bulbar ulcer in children[J].Journal of Pediatrics of Traditional Chinese Medicine,2019,15(01):66-70.[doi:10.16840/j.issn1673-4297.2019.01.22]
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中西医结合治疗小儿幽门螺杆菌相关性十二指肠球部溃疡55例临床观察
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《中医儿科杂志》[ISSN:/CN:62-1176/R]

卷:
15
期数:
2019年01期
页码:
66-70
栏目:
临床研究与报道
出版日期:
2019-01-25

文章信息/Info

Title:
Clinical observation on combination of traditional Chinese and Western medicine in the treatment of Helicobacter Pylori-related duodenal bulbar ulcer in children
作者:
陈红梅 林洁琪 陈燊
福建省福州儿童医院中医科, 福建 福州 350005
Author(s):
CHEN Hongmei LIN Jieqi CHEN Shen
Department of TCM, Fujian Fuzhou Children's Hospital, Fuzhou, Fujian, 350005, China
关键词:
幽门螺杆菌相关性十二指肠球部溃疡小儿中西医结合临床观察
Keywords:
Helicobacter Pylori-related duodenal bulbar ulcerchildrencombination of traditional Chinese and Western medicineclinical observation
分类号:
R725.7
DOI:
10.16840/j.issn1673-4297.2019.01.22
摘要:
目的 观察中西医结合治疗小儿幽门螺杆菌(Hp)相关性十二指肠球部溃疡的临床疗效。方法 选取Hp相关性十二指肠球部溃疡的门诊患儿105例,随机分为对照组和治疗组。对照组50例采用奥美拉唑片、阿莫西林、克拉霉素口服治疗,治疗组55例在对照组治疗方法的基础上加服加味温胆汤。2组均连续治疗4周后,观察2组的中医症状积分变化情况、胃镜检查疗效、Hp转阴情况和综合疗效。结果 治疗前2组的中医症状积分比较,差异无统计学意义(P>0.05),具有可比性。治疗后2组的中医症状积分均较同组治疗前降低,且治疗组较对照组降幅更显著,差异均有统计学意义(P<0.05)。治疗组胃镜检查总有效率为100%,明显优于照组的90%,2组比较,差异有统计学意义(P<0.05)。治疗组Hp转阴率为94.5%,明显优于对照组的84.0%,2组比较,差异有统计学意义(P<0.05)。治疗组综合总有效率为94.5%,明显高于对照组的84.0%,2组比较,差异有统计学意义(P<0.05)。结论 中西医结合治疗小儿Hp相关性十二指肠球部溃疡临床疗效显著。
Abstract:
Objective To observe the clinical efficacy of combination of traditional Chinese and Western medicine in the treatment of Helicobacter Pylori (Hp)-related duodenal bulbar ulcer in children.Methods Totally 105 children patients of duodenal bulbar ulcer and infected with Hp treated in outpatient service were randomly divided into control group and treatment group,the control group with 50 cases was given Western medicines such as omeprazole,amoxicillin and clarithromycin orally;the treatment group with 55 cases was added with Jiawei Wendan Tang (加味温胆汤) on the basis of the control group.The 2 groups were both consecutively treated for 4 weeks, then the symptom scores of TCM,effect of gastroscopy,the condition of Hp turning negative and the comprehensive efficacy were observed.Results Before treatment,there was no statistically significant difference between the two groups in the symptom integral of TCM (P>0.05),and they were comparable.After treatment,the symptom integral of TCM of the 2 groups both decreased than those before treatment,moreover,the treatment group decreased more significantly than the control group,there was statistically significant difference (P<0.05).The total effective rate of gastroscopy in the treatment group was 100%,which was significantly superior to 90% in the control group,there was statistically significant difference between the two groups (P<0.05).The Hp negative-turning rate of the treatment group was 94.5%, which was significantly superior to 84.0% of the control group,there was statistically significant difference between the two groups (P<0.05).The comprehensive efficacy of the treatment group was 94.5%,which was significantly superior to 84.0% of the control group,there was statistically significant difference between the two groups (P<0.05).Conclusion The combination of traditional Chinese and Western medicine has significant clinical efficacy in the treatment of Hp-related duodenal ulcer in children.

参考文献/References:

[1] 李九英.儿童消化性溃疡150例临床分析[J].亚太传统医药,2010,6(6):102-103.
[2] Walsh J H,Peterson W L.The treatment of Helicobacter Pylori in function in the management of peptic ulcen disease[J].N Engl J Med,1995(333):984-991.
[3] 《中华儿科杂志》编辑委员会,中华医学会儿科学分会感染消化学组.小儿慢性胃炎、消化性溃疡胃镜诊断标准[J].中华儿科杂志,2003,41(3):189.
[4] 中华医学会消化病学分会.幽门螺杆菌若干问题的共识意见[J].中华消化杂志,2000,20(2):117-118.
[5] 周仲瑛.中医内科学[M].北京:中国中医药出版社,2007:186-197.
[6] 国家中医药管理局.中医病症诊断疗效标准[S].北京:中国医药科技版社,2012:93-94.
[7] 中华人民共和国卫生部.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2012:151-155.
[8] 王一川,钱辛玲,赵丹.小儿消化性溃疡27例临床分析[J].中国实用医药,2010,5(8):90-91.
[9] 曹炳清.小儿消化性溃疡82例诊治分析[J].中国现代医生,2009,47(22):146-152.
[10] 徐小娟,钱海清,张亮.健脾活血方联合奥美拉唑治疗小儿消化性溃疡临床疗效观察[J].中医儿科杂志,2015,11(3):52-54.
[11] 王良军.中西医结合治疗小儿幽门螺杆菌相关性胃炎73例临床疗效观察[J].中医儿科杂志,2015,11(4):53-55.
[12] 胡玲,劳绍贤,邝枣园,等.对幽门螺杆菌相关胃病脾胃湿热证发生机制的思考[J].中西医结合学报,2008,6(6):565-567.
[13] 徐艺,叶柏,单兆伟,等.中草药单味与复方对幽门螺杆菌抑制作用研究[J].中国中西医结合脾胃杂志,2000,8(5):292-293.
[14] 高学敏.中药学[M].北京:中国中医药出版社,2007:211-212,301-302,347-348.

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备注/Memo

备注/Memo:
作者简介:陈红梅(1966-),女,副主任医师,医学学士。研究方向:中医儿科消化系统疾病。
更新日期/Last Update: 1900-01-01