[1]程慧峰.健脾除湿法联合枸地氯雷他定片治疗小儿湿疹脾虚湿蕴型52例临床观察[J].中医儿科杂志,2019,15(02):56-60.[doi:10.16840/j.issn1673-4297.2019.02.17]
 CHENG Huifeng.Clinical observation on 52 cases of eczema with accumulation of dampness due to spleen-asthenia type treated by invigorating spleen to eliminate dampness method combined with desloratadine citrate disodium tablets[J].Journal of Pediatrics of Traditional Chinese Medicine,2019,15(02):56-60.[doi:10.16840/j.issn1673-4297.2019.02.17]
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健脾除湿法联合枸地氯雷他定片治疗小儿湿疹脾虚湿蕴型52例临床观察
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《中医儿科杂志》[ISSN:/CN:62-1176/R]

卷:
15
期数:
2019年02期
页码:
56-60
栏目:
临床研究与报道
出版日期:
2019-09-25

文章信息/Info

Title:
Clinical observation on 52 cases of eczema with accumulation of dampness due to spleen-asthenia type treated by invigorating spleen to eliminate dampness method combined with desloratadine citrate disodium tablets
作者:
程慧峰
常山县人民医院儿科, 浙江 常山 324200
Author(s):
CHENG Huifeng
Department of Pediatrics, the People's Hospital of Changshan County, Changshan, Zhejiang, 324200, China
关键词:
湿疹小儿脾虚湿蕴型健脾除湿法枸地氯雷他定片临床观察
Keywords:
eczemachildrenaccumulation of dampness due to spleen-asthenia typeinvigorating spleen to eliminate dampness methoddesloratadine citrate disodium tabletsclinical observation
分类号:
R758.23
DOI:
10.16840/j.issn1673-4297.2019.02.17
摘要:
目的 观察健脾除湿法联合枸地氯雷他定片治疗小儿湿疹脾虚湿蕴型的临床疗效及对免疫功能的影响。方法 选取2016年5月至2017年8月我院收治的湿疹脾虚湿蕴型患儿104例,随机分为对照组和治疗组,各52例。对照组单纯给予枸地氯雷他定片口服治疗,治疗组在对照组治疗方法的基础上给予健脾除湿法治疗。2组均连续治疗4周后,观察临床疗效、治疗前后血清细胞因子水平、中医症状积分及免疫功能指标水平。结果 治疗组总有效率为92.31%,显著高于对照组的76.92%,2组比较,差异有统
Abstract:
Objective To observe the clinical efficacy and immunologic function of invigorating spleen to eliminate dampness method combined with desloratadine citrate disodium tablets in the treatment of eczema in children with accumulation of dampness due to spleen-asthenia type.Methods Totally 104 cases of eczema with accumulation of dampness due to spleen-asthenia type admitted to our hospital from May 2016 to August 2017 were randomly divided into control group and treatment group,with 52 cases in each.The control group was given oral desloratadine citrate disodium tablets.On the basis of the control group,the treatment group was given invigorating spleen to eliminate dampness method.After the 2 groups were both consecutively treated for 4 weeks,the clinical efficacy,and serum cytokine levels,TCM symptom scores and the indexes of immunologic function before and after treatment were observed.Results The total effective rate of the treatment group was 92.31%,which was significantly higher than 76.92% of the control group,there was statistically significant difference between the two groups (P<0.05).Before treatment,there were no statistically significant differences in the serum levels of IL-2,IL-4 and IFN-γ between the two groups (P>0.05),and they were comparable.Compared with those of the same groups before treatment,the levels of IL-2 and IFN-γ significantly increased (P<0.05),while IL-4 significantly decreased (P<0.05).Moreover,the extent of improvement of the above-mentioned indexes in the treatment group was all superior to that in the control group,there was statistically significant difference (P<0.05).Before treatment,there were no statistically significant differences in the symptom scores such as itch degree,the appearance and area of the rash between the two groups (P>0.05),and they were comparable.Compared with those of the same groups before treatment,the scores of each symptom in both groups decreased significantly (P<0.05),moreover,the decrease extent of the treatment group was significantly superior to that of the control group,and the difference was statistically significant (P<0.05).Before treatment,there were no statistically significant differences in the levels of CD4+,CD8+ and CD4+/CD8+ between the two groups (P>0.05),and they were comparable.Compared with those of the same groups before treatment,the levels of CD4+ and CD4+/CD8+ significantly increased in the two groups,while the levels of CD8+ significantly decreased (P<0.05),moreover,the extent of improvement of the treatment group was superior to that of the control group,and the difference was statistically significant (P<0.05).Conclusion It has a significant effect to combine invigorating spleen to eliminate dampness method with desloratadine citrate disodium tablets in the treatment of eczema in children with accumulation of dampness due to spleen-asthenia type,not only can it regulate the serum cytokine levels,and improve TCM symptom scores,but also it can markedly improve immunologic function of the children patients.

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备注/Memo

备注/Memo:
作者简介:程慧峰(1976-),男,主治医师,主要从事儿科临床诊疗工作。
更新日期/Last Update: 1900-01-01