[1]丁浏江.自拟清热凉血解毒方辅助治疗小儿过敏性紫癜性肾炎湿毒内蕴型的临床疗效和对凝血机制的影响[J].中医儿科杂志,2019,15(02):60-63.[doi:10.16840/j.issn1673-4297.2019.02.18]
 DING Liujiang.Effect on clinical efficacy and clotting mechanism of self-made Qingre Liangxue Jiedu Fang (清热凉血解毒方) in the adjuvant treatment of nephritis of Schonlein-Henoch purpura in children with retention of noxious dampness in the interior type[J].Journal of Pediatrics of Traditional Chinese Medicine,2019,15(02):60-63.[doi:10.16840/j.issn1673-4297.2019.02.18]
点击复制

自拟清热凉血解毒方辅助治疗小儿过敏性紫癜性肾炎湿毒内蕴型的临床疗效和对凝血机制的影响
分享到:

《中医儿科杂志》[ISSN:/CN:62-1176/R]

卷:
15
期数:
2019年02期
页码:
60-63
栏目:
临床研究与报道
出版日期:
2019-03-25

文章信息/Info

Title:
Effect on clinical efficacy and clotting mechanism of self-made Qingre Liangxue Jiedu Fang (清热凉血解毒方) in the adjuvant treatment of nephritis of Schonlein-Henoch purpura in children with retention of noxious dampness in the interior type
作者:
丁浏江
浙江省中医院中药房, 浙江 杭州 310018
Author(s):
DING Liujiang
Dispensary of TCM, Zhejiang Provincial Hospital of TCM, Hangzhou, Zhejiang, 310018, China
关键词:
过敏性紫癜性肾炎小儿湿毒内蕴型清热凉血解毒方凝血机制临床观察
Keywords:
nephritis of Schonlein-Henoch purpurachildrenretention of noxious dampness in the interior typeQingre Liangxue Jiedu Fang (清热凉血解毒方)clotting mechanismclinical observation
分类号:
R593.1
DOI:
10.16840/j.issn1673-4297.2019.02.18
摘要:
目的 观察自拟清热凉血解毒方辅助治疗对小儿过敏性紫癜性肾炎湿毒内蕴型的临床疗效和凝血机制的影响。方法 选取2017年4月至2018年6月过敏性紫癜性肾炎湿毒内蕴型患儿76例,随机分为对照组和治疗组,各38例。对照组给予常规西药对症治疗,如口服激素及抗凝药物。治疗组在对照组治疗方法的基础上给予口服自拟清热凉血解毒方治疗,每日1剂,早晚分服。2组均连续治疗2周后,观察临床疗效、临床症状消失时间和治疗前后凝血指标的变化。结果 治疗组总有效率为94.74%,高于对照组的7
Abstract:
Objective To observe the effect on clinical efficacy and clotting mechanism of self-made Qingre Liangxue Jiedu Fang (清热凉血解毒方) in the adjuvant treatment of nephritis of Schonlein-Henoch purpura with retention of noxious dampness in the interior type in children.Methods Seventy-six cases of nephritis of Schonlein-Henoch purpura in children with retention of noxious dampness in the interior type from April 2017 to June 2018 were randomly divided into control group and treatment group,with 38 cases in each.The control group was given symptomatic treatment of routine Western medicine,such as oral hormones and anticoagulant drugs.The treatment group was given oral self-made Qingre Liangxue Jiedu Fang on the basis of the control group,1 dose a day,took it separately in the morning and evening.After consecutive treatment for 2 weeks,the clinical efficacy,the disappearance time of clinical symptoms and coagulation index before and after treatment were compared.Results The total effective rate of the treatment group was 94.74%,which was higher than 78.95% of the control group,and there was statistically significant difference between the two groups (P<0.05).After treatment,the disappearance time of skin purpura,abdominal pain and hemafecia in the treatment group were shorter than those of the control group,and there were statistically significant differences between the two groups (P<0.05).Compared with the same group before treatment,D-Dimer,antithrombin,thrombin time,prothrombin time,activated partial thromboplastin time,fibrinogen,platelet index all improved to some extent in the two groups after treatment (P<0.05),moreover,these of the treatment group were significantly superior to those of the control group,the differences were statistically significant (P<0.05).Conclusion It has satisfactory clinical efficacy to use self-made Qingre Liangxue Jiedu Fang in the adjuvant treatment of nephritis of Schonlein-Henoch purpura with retention of noxious dampness in the interior type in children.It not only significantly shortens the disappearance time of clinical symptoms,but also effectively improves the coagulation,which deserves clinical promotion and application.

参考文献/References:

[1] 刘丽君,于静,李宇宁.儿童过敏性紫癜325例回顾性分析[J].中国当代儿科杂志, 2015, 17(10):1079-1083.
[2] 中华医学会儿科学分会肾脏病学组.紫癜性肾炎的诊断与治疗(草案)[J].中华儿科杂志, 2001, 39(12):748-749.
[3] 汪受传,虞坚尔.中医儿科学[M].3版.北京:中国中医药出版社,2012:281.
[4] 郑筱萸. 中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002:61-62.
[5] 王凤英, 李晓忠, 王兴东,等. 肾小球内纤维蛋白原沉积在儿童过敏性紫癜性肾炎中的意义[J]. 临床儿科杂志,2018,36(3):182-187.
[6] 迟妍. 凉血化瘀通络方治疗小儿过敏性紫癜肾炎的临床疗效观察[J]. 中国医药指南,2018,16(4):165.
[7] 陈团营, 朱珊, 祝志朋,等. 清热活血方药对过敏性紫癜肾炎患儿t-PA和PAI-1水平的影响[J]. 中华中医药杂志,2018,33(4):1574-1576.
[8] 何军民. 凉血肾愈汤配合西药治疗小儿血热阻络型过敏性紫癜性肾炎36例临床观察[J]. 中医儿科杂志, 2016,12(5):52-55.

相似文献/References:

[1]辛晶.刘振寰教授治疗小儿屏气发作经验[J].中医儿科杂志,2015,(04):3.
 XIN Jing.Professor LIU Zhenhuan’s experience in treating infantile breath holding spell[J].Journal of Pediatrics of Traditional Chinese Medicine,2015,(02):3.
[2]潘馨,邵梦洁.穴位敷贴防治小儿感染后气道高反应咳嗽110例临床观察[J].中医儿科杂志,2015,(04):16.
 PAN Xin,SHAO Mengjie.Clinical observation of acupoint sticking in the treatment of 110 cases of children airway hyper reactivity cough after infection[J].Journal of Pediatrics of Traditional Chinese Medicine,2015,(02):16.
[3]谢敏,吕旭艳.黄芪颗粒治疗小儿反复呼吸道感染(营卫失和型)65例临床疗效分析[J].中医儿科杂志,2015,(04):20.
 XIE Min,LUE Xuyan.Clinical efficacy of Astragalus Particles in treating children recurrent respiratory tract infection of ying-wei disharmony type[J].Journal of Pediatrics of Traditional Chinese Medicine,2015,(02):20.
[4]江春燕,李成国,姚伟光.葶苈大枣泻肺汤加味外敷治疗小儿痰湿咳嗽200例临床观察[J].中医儿科杂志,2015,(04):28.
 JIANG Chunyan,LI Chengguo,YAO Weiguang.Clinical observation of external application of modified Tingli Dazao Xiefei Tang in the treatment of 200 cases of children with phlegm damp cough[J].Journal of Pediatrics of Traditional Chinese Medicine,2015,(02):28.
[5]汪永峰.中西医结合治疗小儿手足口病54例临床观察[J].中医儿科杂志,2015,(04):44.
 WANG Yongfeng.Clinical observation of integrated western and TCM medicine in treating 54 cases of children hand-foot-mouth disease[J].Journal of Pediatrics of Traditional Chinese Medicine,2015,(02):44.
[6]荣志云,张源,丛丽.小儿积滞发病的相关因素调查[J].中医儿科杂志,2015,(04):47.
 Rongzhiyun,Zhangyuan,Cong Li.Investigation on related factors of the pathogenesis of infantile dyspepsia[J].Journal of Pediatrics of Traditional Chinese Medicine,2015,(02):47.
[7]王良军.中西医结合治疗小儿幽门螺杆菌相关性胃炎73例临床观察[J].中医儿科杂志,2015,(04):53.
 WANG Liangjun.Clinical observation of TCM combined with western medicines in treating 73 cases of children Hp-associated gastritis[J].Journal of Pediatrics of Traditional Chinese Medicine,2015,(02):53.
[8]张梦桃,张映芬,李玉秀,等.脑瘫患儿睡眠障碍的护理[J].中医儿科杂志,2015,(04):70.
 ZHANG Mengtao,ZHANG Yingfen,LI Yuxiu,et al.Nursing care on sleep disorders of children with cerebral palsy[J].Journal of Pediatrics of Traditional Chinese Medicine,2015,(02):70.
[9]邬颖菲.苍苓止泻口服液辅助治疗小儿脾虚泻的临床疗效及护理措施[J].中医儿科杂志,2015,(04):73.
 WU Yingfei.Clinical efficacy and nursing care in the adjuvant treatment of spleen deficiency diarrhea in children with Cangling Zhixie Koufuye[J].Journal of Pediatrics of Traditional Chinese Medicine,2015,(02):73.
[10]张春玲.倪晓红主任医师论治小儿疳积经验[J].中医儿科杂志,2015,(02):10.
 ZHANG Chunling.Chief physician NI Xiaohong’s experience on the treatment of infantile malnutrition[J].Journal of Pediatrics of Traditional Chinese Medicine,2015,(02):10.
[11]何军民.凉血肾愈汤配合西药治疗小儿血热阻络型过敏性紫癜性肾炎36例临床观察[J].中医儿科杂志,2016,(05):52.[doi:10.16840/j.issn1673-4297.2016.05.17]
 HE Junmin.Clinical observation of 36 cases of pediatric Henoch-Schonlein purpura nephritis of hot blood stasis in collaterals syndrome treated with Western medicine and Liangxue Shenyu Tang[J].Journal of Pediatrics of Traditional Chinese Medicine,2016,(02):52.[doi:10.16840/j.issn1673-4297.2016.05.17]

备注/Memo

备注/Memo:
作者简介:丁浏江(1987-),男,中药师,理学学士,主要从事中药治疗临床疾病研究工作。
更新日期/Last Update: 1900-01-01